Annotation Detail
Information
- Associated Genes
- PGR
- Associated Variants
-
PGR EXPRESSION
PGR EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In patients with breast cancer, those with low expression of PgR treated with tamoxifen had the same disease-free survial as those with high expression of PgR.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/502
- Gene URL
- https://civic.genome.wustl.edu/links/genes/76
- Variant URL
- https://civic.genome.wustl.edu/links/variants/210
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Does Not Support
- Drug
- Exemestane,Tamoxifen
- Evidence Level
- B
- Clinical Significance
- N/A
- Pubmed
- 21422407
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Exemestane | N/A | false |
| Tamoxifen | N/A | false |