Annotation Detail
Information
- Associated Genes
- DNMT3A
- Associated Variants
-
DNMT3A R882
DNMT3A R882 - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- In a large cohort (n=1770) of AML patients (18-60 years old), DNMT3A mutation status (65.4% of which were R882) had no prognostic value for overall, relapse free and event free survival. This was true for cytogenetically normal AML and the entire cohort.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/50
- Gene URL
- https://civic.genome.wustl.edu/links/genes/18
- Variant URL
- https://civic.genome.wustl.edu/links/variants/32
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Does Not Support
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 23632886
Drugs