Annotation Detail
Information
- Associated Genes
- KRAS
- Associated Variants
-
KRAS Q61
KRAS Q61 - Associated Disease
- multiple myeloma
- Source Database
- CIViC Evidence
- Description
- In a retrospective study of 439 patients with multiple myeloma enrolled in a clinical trial, 28 had mutaions in KRAS. Those with mutations had worse overall and progression free survival than those without mutations.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/489
- Gene URL
- https://civic.genome.wustl.edu/links/genes/30
- Variant URL
- https://civic.genome.wustl.edu/links/variants/203
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- Multiple Myeloma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 18528420
Drugs