Annotation Detail

Information
Associated Genes
ARID1A
Associated Variants
ARID1A P1175FS*5
ARID1A P1175FS*5
Associated Disease
ovarian clear cell carcinoma
Source Database
CIViC Evidence
Description
In an in vitro study, a HCH1 cell line expressing ARID1A P1175fs*5 mutation demonstrated increased sensitivity to dasatinib treatment, compared to ES2, KK and RMG-1 cells expressing wild-type ARID1A. Sensitivity was determined by assessing cell survival.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/4826
Gene URL
https://civic.genome.wustl.edu/links/genes/6559
Variant URL
https://civic.genome.wustl.edu/links/variants/1682
Evidence Type
Predictive
Disease
Ovarian Clear Cell Carcinoma
Evidence Direction
Supports
Drug
Dasatinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
27364904
Drugs
Drug NameSensitivitySupported
DasatinibSensitivitytrue