Annotation Detail
Information
- Associated Genes
- IDH1
- Associated Variants
-
IDH1 R132
IDH1 R132 - Associated Disease
- malignant astrocytoma
- Source Database
- CIViC Evidence
- Description
- In patients with anaplastic astrocytoma, those with mutations at R132 of IDH1 had better overall survival than wild-type patients.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/481
- Gene URL
- https://civic.genome.wustl.edu/links/genes/26
- Variant URL
- https://civic.genome.wustl.edu/links/variants/58
- Rating
- 5
- Evidence Type
- Prognostic
- Disease
- Astrocytoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Better Outcome
- Pubmed
- 19228619
Drugs