Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR COPY NUMBER VARIATION
(
ENST00000275493.7 )
EGFR COPY NUMBER VARIATION ( ENST00000275493.7 ) - Associated Disease
- head and neck squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In 134 patients with head and neck squamous cancer 32 had copy number variations. Tumors with variation (either increase or decrease) in copy number of EGFR had worse overall, cancer-specific, and disease-free survival.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/472
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/191
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- Head And Neck Squamous Cell Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 17538160
Drugs