Annotation Detail
Information
- Associated Genes
- DNMT3A
- Associated Variants
-
DNMT3A MUTATION
DNMT3A MUTATION - Associated Disease
- T-cell acute lymphoblastic leukemia
- Source Database
- CIViC Evidence
- Description
- In adult patients with early (n = 30), cortical (n = 30), mature (n = 3) or unknown (n = 8) T-cell acute lymphoblastic leukemia, those with mutations in DNMT3A (n=12) had shorter overall survival than wild-type patients (n=59; p=0.011). This was also true for the subset of patients with early T-ALL DNMT3A-mutated (n = 8) compared to wild-type patients (n = 22; p=0.005).
- Evidence Direction
- Supports
- Evidence Level
- B
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/469
- Gene URL
- https://civic.genome.wustl.edu/links/genes/18
- Variant URL
- https://civic.genome.wustl.edu/links/variants/189
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- T-cell Acute Lymphoblastic Leukemia
- Clinical Significance
- Poor Outcome
- Pubmed
- 23341344
Drugs