Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM MUTATION
ATM MUTATION - Associated Disease
- hematologic cancer
- Source Database
- CIViC Evidence
- Description
- Olaparib was found to inhibit cancer cell growth in ATM mutant cell lines of several blood cancers including Lymphoblastoid Leukemia, Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia, and in a murine xenograft model of Mantle Cell Lymphoma.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/455
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/178
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Hematologic Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 20739657
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Sensitivity | true |