Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM MUTATION
ATM MUTATION - Associated Disease
- glioblastoma
- Source Database
- CIViC Evidence
- Description
- Glioblastoma cell lines were shown to have increased sensitivity to Temozolomide when siRNA-induced ATM knockdown was applied.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/452
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/178
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Glioblastoma Multiforme
- Evidence Direction
- Supports
- Drug
- Temozolomide
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23960094
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |