Annotation Detail
Information
- Associated Genes
- AR
- Associated Variants
-
AR p.Phe877Leu (p.F877L)
(
ENST00000374690.9,
ENST00000396044.8 )
AR p.Phe877Leu (p.F877L) ( ENST00000374690.9, ENST00000396044.8 ) - Associated Disease
- prostate cancer
- Source Database
- CIViC Evidence
- Description
- Mutations F876L in the ligand binding domain of the androgen receptor confered resistance to enzalutamide and ARN-509, causing these compounds to function as partial agonists in two prostate cancer cell lines.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/447
- Gene URL
- https://civic.genome.wustl.edu/links/genes/67
- Variant URL
- https://civic.genome.wustl.edu/links/variants/175
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Prostate Cancer
- Evidence Direction
- Supports
- Drug
- Apalutamide,Enzalutamide
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 23779130
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Apalutamide | Resitance or Non-Reponse | true |
| Enzalutamide | Resitance or Non-Reponse | true |