Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
- ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K)
- Associated Disease
- chronic myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Prior to dasatinib treatment, one imatinib-resistant patient with chronic myeloid leukemia in chronic phase had the BCR-ABL1 fusion with the E255K secondary variant in 12/12 bacterial clones generated using peripheral blood RNA. They had complete best hematologic and minimal best cytogenetic responses to dasatinib which were comparable to responses in patients with unmutated BCR-ABL1.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/4353
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4
- Variant URL
- https://civic.genome.wustl.edu/links/variants/3
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Chronic Myeloid Leukemia
- Evidence Direction
- Does Not Support
- Drug
- Dasatinib
- Evidence Level
- C
- Clinical Significance
- Resistance
- Pubmed
- 16775234
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dasatinib | Resitance or Non-Reponse | false |