Annotation Detail
Information
- Associated Genes
- IGF2
- Associated Variants
-
IGF2 OVEREXPRESSION
IGF2 OVEREXPRESSION - Associated Disease
- prostate cancer
- Source Database
- CIViC Evidence
- Description
- OSI-906, an IGF1R/INSR inhibitor, sensitizes cell lines to docetaxel and cabazitaxel, resulting in better overall survival in mouse xenografts of patient derived chemotherapy resistant castration-resistant prostate cancer cell lines.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/414
- Gene URL
- https://civic.genome.wustl.edu/links/genes/60
- Variant URL
- https://civic.genome.wustl.edu/links/variants/156
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Prostate Cancer
- Evidence Direction
- Supports
- Drug
- Cabazitaxel,Docetaxel,Linsitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25670080
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cabazitaxel | Sensitivity | true |
| Docetaxel | Sensitivity | true |
| Linsitinib | Sensitivity | true |