Annotation Detail

Information
Associated Genes
FLT3
Associated Variants
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
Associated Disease
acute myeloid leukemia
Source Database
CIViC Evidence
Description
In a retrospective study of 15 acute myeloid leukemia patients, the patients with FLT3 D835 mutation (n=2) were associated with improved response to sunitinib treatment (2/2 vs. 2/7) compared to FLT3 wild-type patients. The FLT3 D835 mutation positive patients were treated with sunitinib after failure of standard chemotherapy. After 4wk of sunitinib therapy, one patient showed morphological response and the other patient showed partial response to sunitinib therapy.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/4022
Gene URL
https://civic.genome.wustl.edu/links/genes/24
Variant URL
https://civic.genome.wustl.edu/links/variants/1302
Evidence Type
Predictive
Disease
Acute Myeloid Leukemia
Evidence Direction
Supports
Drug
Sunitinib
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
15459012
Drugs
Drug NameSensitivitySupported
SunitinibSensitivitytrue