Annotation Detail
Information
- Associated Genes
- KRAS
- Associated Variants
-
KRAS p.Gly12Ser (p.G12S)
(
ENST00000685328.1,
ENST00000256078.10,
ENST00000311936.8,
ENST00000556131.2,
ENST00000557334.6,
ENST00000686969.1,
ENST00000688940.1,
ENST00000692768.1,
ENST00000693229.1 )
KRAS p.Gly12Ser (p.G12S) ( ENST00000256078.10, ENST00000311936.8, ENST00000685328.1, ENST00000686969.1, ENST00000556131.2, ENST00000557334.6, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- In an in vitro study, a SW48 cell line expressing KRAS G12S mutation demonstrated decreased sensitivity to regorafenib treatment (IC50: 264.23 nmol vs. 114.28 nmol, P<0.01) compared to SW48 cells expressing KRAS wild-type. Resistance was determined by assessing cell viability.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/4012
- Gene URL
- https://civic.genome.wustl.edu/links/genes/30
- Variant URL
- https://civic.genome.wustl.edu/links/variants/913
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Regorafenib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 26161928
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Regorafenib | Resitance or Non-Reponse | true |