Annotation Detail
Information
- Associated Genes
- U2AF1
- Associated Variants
-
U2AF1 p.Gln157Pro (p.Q157P)
(
ENST00000291552.9,
ENST00000380276.6,
ENST00000459639.5 )
U2AF1 p.Gln157Pro (p.Q157P) ( ENST00000291552.9, ENST00000380276.6, ENST00000459639.5 ) - Associated Disease
- myelodysplastic syndrome
- Source Database
- CIViC Evidence
- Description
- After adjusting for age and cancer stage, presence of U2AF mutation such as Q157P/R is prognostic for poorer survival outcomes in patients with MDS.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/400
- Gene URL
- https://civic.genome.wustl.edu/links/genes/48
- Variant URL
- https://civic.genome.wustl.edu/links/variants/127
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Myelodysplastic Syndrome
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 23861105
Drugs