Annotation Detail
Information
- Associated Genes
- ARAF
- Associated Variants
-
ARAF p.Ser214Cys (p.S214C)
(
ENST00000377045.9 )
ARAF p.Ser214Cys (p.S214C) ( ENST00000377045.9 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Sorafenib can inhibit ARF-mediated MEK phosphorylation and soft agar colony formation of AALE cells expressing ARAF S214C in vitro.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/40
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3
- Variant URL
- https://civic.genome.wustl.edu/links/variants/10
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Sorafenib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24569458
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sorafenib | Sensitivity | true |