Annotation Detail
Information
- Associated Genes
- ALK
- Associated Variants
-
ALK p.Phe1174Leu (p.F1174L)
(
ENST00000389048.8,
ENST00000618119.4,
ENST00000642122.1 )
ALK p.Phe1174Leu (p.F1174L) ( ENST00000618119.4, ENST00000642122.1, ENST00000389048.8 ) - Associated Disease
- inflammatory myofibroblastic tumor
- Source Database
- CIViC Evidence
- Description
- Ba/F3 cells expressing the RANBP2-ALK fusion containing an F1174L mutation were more resistant to crizotinib treatment than Ba/F3 cells expressing RANBP2-ALK without this mutation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/32
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1
- Variant URL
- https://civic.genome.wustl.edu/links/variants/8
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Inflammatory Myofibroblastic Tumor
- Evidence Direction
- Supports
- Drug
- Crizotinib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 21030459
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Crizotinib | Resitance or Non-Reponse | true |