Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA p.Glu542Lys (p.E542K) ( ENST00000643187.1, ENST00000263967.4 )
PIK3CA p.Glu542Lys (p.E542K) ( ENST00000263967.4, ENST00000643187.1 )
Associated Disease
breast cancer
Source Database
CIViC Evidence
Description
Rapamycin inhibits transformation induced by mutation in PIK3CA.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/311
Gene URL
https://civic.genome.wustl.edu/links/genes/37
Variant URL
https://civic.genome.wustl.edu/links/variants/103
Rating
3
Evidence Type
Predictive
Disease
Breast Cancer
Evidence Direction
Supports
Drug
Sirolimus
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
15647370
Drugs
Drug NameSensitivitySupported
SirolimusSensitivitytrue