Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Asp835Val (p.D835V)
(
ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 ) - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Murine Ba/F3 cells with FLT3 D835V mutation were assessed as sensitive to both AS602868 and AG1296.(IC50 = 1.85uM and IC50 = 4.55uM, respectively)
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/3034
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1302
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- AS602868,Tyrphostin AG 1296
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 17330097
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AS602868 | Sensitivity | true |
| Tyrphostin AG 1296 | Sensitivity | true |