Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 OVEREXPRESSION
(
ENST00000269305.9 )
TP53 OVEREXPRESSION ( ENST00000269305.9 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- In a study involving patients with invasive ovarian carcinoma who had undergone surgery, a subset of 73 patients were classified via response to platinum-based chemotherapy as sensitive or resistant/refractory and tested for p53 overexpression (>10% postive stained nuclei). 78% of p53 negative patients were classified as sensitive, in compariston to 39% of p53 positive patients (p=0.001).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/3013
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1306
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Cisplatin,Carboplatin
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 11595686
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Carboplatin | Resitance or Non-Reponse | true |
| Cisplatin | Resitance or Non-Reponse | true |