Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Asp835Val (p.D835V)
(
ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 ) - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Murine Ba/F3 cell line has a restrictive sensitivity to Quizartinib(AC220), a second generation class II tyrosine kinase inhibitor. (IC50 for proliferation = 172nM, IC50 for induction of apoptosis = 888nM)
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/3012
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1302
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Does Not Support
- Drug
- Quizartinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23497317
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Quizartinib | Sensitivity | false |