Annotation Detail

Information
Associated Genes
FLT3
Associated Variants
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
Associated Disease
acute myeloid leukemia
Source Database
CIViC Evidence
Description
SU11248 + Daunorubicin has a synergic effect on Murine Ba/F3 cells with FLT3 D835V mutation. (Combination Index = 0.82 for ED50, Combination Index = 0.72 for ED75, Combination Index = 0.64 for ED90)
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/3010
Gene URL
https://civic.genome.wustl.edu/links/genes/24
Variant URL
https://civic.genome.wustl.edu/links/variants/1302
Rating
2
Evidence Type
Predictive
Disease
Acute Myeloid Leukemia
Evidence Direction
Supports
Drug
Sunitinib,Daunorubicin
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
15304385
Drugs
Drug NameSensitivitySupported
DaunorubicinSensitivitytrue
SunitinibSensitivitytrue