Annotation Detail
Information
- Associated Genes
- GATA2
- Associated Variants
-
GATA2 EXPRESSION
GATA2 EXPRESSION - Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- Targeting overactive GATA2-mediated pathways with inhibitors bortezomib and fasudil led to dramatic tumor regression.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/301
- Gene URL
- https://civic.genome.wustl.edu/links/genes/25
- Variant URL
- https://civic.genome.wustl.edu/links/variants/57
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Fasudil,Bortezomib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22541434
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bortezomib | Sensitivity | true |
| Fasudil | Sensitivity | true |