Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 p.Asp835Val (p.D835V)
(
ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 ) - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- SU11248 + Cytarabin has a synergic effect on Murine Ba/F3 cells with FLT3 D835V mutation (Combination Index = 0.59 for ED50, Combination Index = 0.71 for ED75, Combination Index = 0.82 for ED90)
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/3009
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1302
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Sunitinib,Cytarabine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 15304385
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cytarabine | Sensitivity | true |
| Sunitinib | Sensitivity | true |