Annotation Detail

Information
Associated Genes
FLT3
Associated Variants
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
FLT3 p.Asp835Val (p.D835V) ( ENST00000241453.12 )
Associated Disease
acute myeloid leukemia
Source Database
CIViC Evidence
Description
Murine Ba/F3 cells with FLT3 D835V mutation were assessed as not sensitive to SU11248 (Sunitinib) with dose required to inhibit proliferation of cells to 50% of untreated controls ED50 = 110nM.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/3008
Gene URL
https://civic.genome.wustl.edu/links/genes/24
Variant URL
https://civic.genome.wustl.edu/links/variants/1302
Rating
3
Evidence Type
Predictive
Disease
Acute Myeloid Leukemia
Evidence Direction
Does Not Support
Drug
Sunitinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
15304385
Drugs
Drug NameSensitivitySupported
SunitinibSensitivityfalse