Annotation Detail

Information
Associated Genes
DNMT3A
Associated Variants
DNMT3A R882
DNMT3A R882
Associated Disease
acute myeloid leukemia
Source Database
CIViC Evidence
Description
DNMT3A R882 mutations occur most often in de novo AML patients with intermediate risk cytogenetics (39/194 intermediate risk patients vs 0/89 low and high risk).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/3
Gene URL
https://civic.genome.wustl.edu/links/genes/18
Variant URL
https://civic.genome.wustl.edu/links/variants/32
Rating
2
Evidence Type
Diagnostic
Disease
Acute Myeloid Leukemia
Evidence Direction
Supports
Evidence Level
B
Clinical Significance
Positive
Pubmed
22081665
Drugs