Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 ITD
FLT3 ITD - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- AG1296 is effective in triggering apoptosis in Ba/F3 and primary AML cells with FLT3 internal tandem repeat.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/299
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/55
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Tyrphostin AG 1296
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 12357354
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tyrphostin AG 1296 | Sensitivity | true |