Annotation Detail
Information
- Associated Genes
- ARID1A
- Associated Variants
-
ARID1A MUTATION
ARID1A MUTATION - Associated Disease
- ovarian clear cell carcinoma
- Source Database
- CIViC Evidence
- Description
- High-throughput drug screens in OCCC tumor cell model identified synthetic lethal (SL) interaction between the kinase inhibitor dasatinib and ARID1A mutation. Imposing ARID1A deficiency upon a variety of human or mouse cells induced dasatinib sensitivity, both in vitro and in vivo.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2982
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6559
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1293
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Clear Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Dasatinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27364904
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dasatinib | Sensitivity | true |