Annotation Detail
Information
- Associated Genes
- FGFR2
- Associated Variants
- FGFR2 FGFR2-TACC3
- Associated Disease
- cholangiocarcinoma
- Source Database
- CIViC Evidence
- Description
- In a 43 year old female patient with this fusion in intrahepatic cholangiocarcinoma. Both pazopanib and ponatinib separately resulted in minor tumor shrinkage. This fusion is also shown to be recurrent in multiple other cancer types.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/296
- Gene URL
- https://civic.genome.wustl.edu/links/genes/22
- Variant URL
- https://civic.genome.wustl.edu/links/variants/54
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Cholangiocarcinoma
- Evidence Direction
- Supports
- Drug
- Ponatinib,Pazopanib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24550739