Annotation Detail
Information
- Associated Genes
- NTRK1
- Associated Variants
- NTRK1 NTRK1 FUSIONS NTRK1 NTRK1 FUSIONS
- Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- 1378 cases of NSCLC were screened. One patient (frequency 0.1%) with a NTRK1 gene rearrangement (SQSTM1-NTRK1 Fusion) was treated with entrectinib in a phase 1 study. The patient had resolution of prior dyspnea and pain within 3 weeks. CT scans showed a partial response and complete resolution of brain metastases. The patient has continued treatment for over 6 months with ongoing PR.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2947
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3983
- Variant URL
- https://civic.genome.wustl.edu/links/variants/419
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Entrectinib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26565381
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Entrectinib | Sensitivity | true |