Annotation Detail

Information
Associated Genes
ERBB2
Associated Variants
ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
Associated Disease
breast cancer
Source Database
CIViC Evidence
Description
The L755S mutation showed mild response to neratinib in MCF10A cell lines retrovirally transduced with wildtype or mutant ERBB2.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/283
Gene URL
https://civic.genome.wustl.edu/links/genes/20
Variant URL
https://civic.genome.wustl.edu/links/variants/39
Rating
5
Evidence Type
Predictive
Disease
Breast Cancer
Evidence Direction
Supports
Drug
Neratinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
23220880
Drugs
Drug NameSensitivitySupported
NeratinibSensitivitytrue