Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 DNA BINDING DOMAIN MUTATION
TP53 DNA BINDING DOMAIN MUTATION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In a study 202 breast cancer patients undergoing first line tamoxifen treatment, 65 patients had mutations in TP53. Among the p53 wild type population a 66% response rate was reported, where response was considered as complete response, partial response or stable disease. In a patient subgroup with mutations in p53 amino acids that directly interact with DNA, 2 of 11 (18%) of patients responded to tamoxifen.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2783
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/242
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Tamoxifen
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 10786679
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Tamoxifen | Resitance or Non-Reponse | true |