Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 OVEREXPRESSION
(
ENST00000269305.9 )
TP53 OVEREXPRESSION ( ENST00000269305.9 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- p53 overexpression (>10% positive stained nuclei) was found in 110 cases from a 178 patient cohort with invasive ovarian carcinoma who had undergone surgery. Overexpression of p53 was correlated with poor differentiation (p<0.001) and high S-phase fraction (p<0.001).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2697
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1306
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 11595686
Drugs