Annotation Detail
Information
- Associated Genes
- DDR2
- Associated Variants
-
DDR2 p.Ile638Phe (p.I638F)
(
ENST00000446985.6,
ENST00000367921.8,
ENST00000367922.7 )
DDR2 p.Ile638Phe (p.I638F) ( ENST00000367921.8, ENST00000367922.7, ENST00000446985.6 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In 3T3 fibroblasts expressing the I638F mutation have to be sensitive to the tyrosine kinase inhibitor dasatinib.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/269
- Gene URL
- https://civic.genome.wustl.edu/links/genes/51
- Variant URL
- https://civic.genome.wustl.edu/links/variants/143
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Dasatinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 22328973
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dasatinib | Sensitivity | true |