Annotation Detail
Information
- Associated Genes
- CDK4
- Associated Variants
-
CDK4 EXPRESSION
CDK4 EXPRESSION - Associated Disease
- estrogen-receptor positive breast cancer
- Source Database
- CIViC Evidence
- Description
- In mouse xenograft studies of PIK3CA mutant breast cancers, the combination of PI3K and CDK4/6 inhibitors overcomes intrinsic and adaptive resistance leading to tumor regressions.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/264
- Gene URL
- https://civic.genome.wustl.edu/links/genes/13
- Variant URL
- https://civic.genome.wustl.edu/links/variants/25
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Estrogen-receptor Positive Breast Cancer
- Evidence Direction
- Supports
- Drug
- Alpelisib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25002028
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Alpelisib | Sensitivity | true |