Annotation Detail
Information
- Associated Genes
- CCND3
- Associated Variants
-
CCND3 LOSS
(
ENST00000372991.9 )
CCND3 LOSS ( ENST00000372991.9 ) - Associated Disease
- obsolete T-cell lymphoblastic leukemia/lymphoma
- Source Database
- CIViC Evidence
- Description
- Treatment of Notch-driven T-cell leukemia in Ccnd3 knockout mice with Palbociclib (PD-0332991) significantly increased median survival.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/263
- Gene URL
- https://civic.genome.wustl.edu/links/genes/10
- Variant URL
- https://civic.genome.wustl.edu/links/variants/23
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- T-cell Lymphoblastic Leukemia/lymphoma
- Evidence Direction
- Supports
- Drug
- Palbociclib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23079656
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Palbociclib | Sensitivity | true |