Annotation Detail
Information
- Associated Genes
- IDH1
- Associated Variants
-
IDH1 p.Arg132Cys (p.R132C)
(
ENST00000345146.7,
ENST00000446179.5,
ENST00000415913.5 )
IDH1 p.Arg132Cys (p.R132C) ( ENST00000345146.7, ENST00000415913.5, ENST00000446179.5 ) - Associated Disease
- high grade glioma
- Source Database
- CIViC Evidence
- Description
- In an experimental in vitro study, glioma cells expressing IDH1 R132C were associated with sensitivity to AGI-5198 (IC50: 0.16M vs. IC50 > 100.00M), as compared to cells expressing wild-type IDH1. Sensitivity was determined by assessing cell growth.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2329
- Gene URL
- https://civic.genome.wustl.edu/links/genes/26
- Variant URL
- https://civic.genome.wustl.edu/links/variants/59
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Malignant Glioma
- Evidence Direction
- Supports
- Drug
- AGI-5198
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23558169
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| AGI-5198 | Sensitivity | true |