Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 p.Arg273Cys (p.R273C)
(
ENST00000576024.2,
ENST00000510385.5,
ENST00000504937.5,
ENST00000604348.6,
ENST00000269305.9,
ENST00000359597.8,
ENST00000420246.6,
ENST00000445888.6,
ENST00000413465.6,
ENST00000455263.6,
ENST00000504290.5,
ENST00000610292.4,
ENST00000610538.4,
ENST00000610623.4,
ENST00000618944.4,
ENST00000619186.4,
ENST00000619485.4,
ENST00000620739.4,
ENST00000622645.4,
ENST00000714356.1,
ENST00000714357.1,
ENST00000714359.1,
ENST00000714408.1,
ENST00000714409.1 )
TP53 p.Arg273Cys (p.R273C) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) - Associated Disease
- stomach carcinoma
- Source Database
- CIViC Evidence
- Description
- A female patient taking part in a 25 patient gastric cancer trial was diagnosed at age 46, and received preoperative high dose chemotherapy (HDCT). Japanese Society for Gastric Cancer Response Score was 0. Resection was performed on patients with greater than 50% size reduction of the lesion. This patient did not undergo resection, and had on overall survival of 7.4 months.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/2292
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/121
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Stomach Carcinoma
- Evidence Direction
- Does Not Support
- Drug
- Cisplatin,Etoposide,Mitomycin
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 14514923