Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM MUTATION
ATM MUTATION - Associated Disease
- prostate cancer
- Source Database
- CIViC Evidence
- Description
- Response to olaparib was observed in 4 of 5 with prostate cancer patients with ATM aberrations (2 germline).
- Variant Origin
- germline
- Variant Origin
- Rare Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1960
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/178
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Prostate Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26510020
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Sensitivity | true |