Annotation Detail
Information
- Associated Genes
- FGFR2
- Associated Variants
-
FGFR2 MUTATION
FGFR2 MUTATION - Associated Disease
- cholangiocarcinoma
- Source Database
- CIViC Evidence
- Description
- Phase 1 study of FGFR-inhibitor BGJ398 in advanced cancer with FGFR-aberrations. Among three patients with cholangiocarcinoma and FGFR2 aberrations (2 fusions, 1 mutation), all three had stable disease with a reduced tumor burden.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1912
- Gene URL
- https://civic.genome.wustl.edu/links/genes/22
- Variant URL
- https://civic.genome.wustl.edu/links/variants/511
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Cholangiocarcinoma
- Evidence Direction
- Supports
- Drug
- Infigratinib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27870574
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Infigratinib | Sensitivity | true |