Annotation Detail
Information
- Associated Genes
- PTPRB
- Associated Variants
-
PTPRB LOSS-OF-FUNCTION
PTPRB LOSS-OF-FUNCTION - Associated Disease
- angiosarcoma
- Source Database
- CIViC Evidence
- Description
- The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored truncating mutations in 10 of 39 angiosarcomas (26%) which correlated with MYC amplifications. In HUVEC cell line model, silencing of PTPRB induced features of angiogenesis which were abolished in the presence of sunitinib or vatalinib, inhibitors of VEGFR.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1895
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4690
- Variant URL
- https://civic.genome.wustl.edu/links/variants/819
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Angiosarcoma
- Evidence Direction
- Supports
- Drug
- Sunitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24633157
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sunitinib | Sensitivity | true |