Annotation Detail

Information
Associated Genes
NTRK1
Associated Variants
NTRK1 SQSTM1-NTRK1
Associated Disease
lung non-small cell carcinoma
Source Database
CIViC Evidence
Description
In 1378 cases of NSCLC screened for NTRK1 rearrangements, 2 were identified (frequency 0.1%). One patient with SQSTM1-NTRK1 was treated with entrectinib in a phase 1 study. The patient had resolution of prior dyspnea and pain within 3 weeks. CT scans showed a partial response and complete resolution of brain metastases. The patient has continued treatment for over 6 months with ongoing PR.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1868
Gene URL
https://civic.genome.wustl.edu/links/genes/3983
Variant URL
https://civic.genome.wustl.edu/links/variants/800
Rating
3
Evidence Type
Predictive
Disease
Lung Non-small Cell Carcinoma
Evidence Direction
Supports
Drug
Entrectinib
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
26565381
Drugs
Drug NameSensitivitySupported
EntrectinibSensitivitytrue