Annotation Detail
Information
- Associated Genes
- RRM2
- Associated Variants
-
RRM2 OVEREXPRESSION
(
ENST00000360566.6 )
RRM2 OVEREXPRESSION ( ENST00000360566.6 ) - Associated Disease
- pancreatic cancer
- Source Database
- CIViC Evidence
- Description
- The mRNA expression level of RRM2 was analyzed by RT-PCR in 3 human pancreatic cancer cell lines cultured in incrementally increased concentrations of gemcitabine. Expression levels of RRM2 progressively increased during the development of gemcitabine resistance.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1860
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5052
- Variant URL
- https://civic.genome.wustl.edu/links/variants/796
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Pancreatic Cancer
- Evidence Direction
- Supports
- Drug
- Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 17224927
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Gemcitabine | Resitance or Non-Reponse | true |