Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR EXON 20 INSERTION
EGFR EXON 20 INSERTION - Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- In retrospective analysis of trials, afatinib conferred limited clinical benefit to patients with EGFR exon 20 insertion mutations (N=23). Only 2 patients had objective responses.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1809
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/726
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Afatinib
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 26051236
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Afatinib | Resitance or Non-Reponse | true |