Annotation Detail

Information
Associated Genes
UGT1A1
Associated Variants
UGT1A6 c.862-6799_862-6798insTATATATATATATA, UGT1A5 c.868-6799_868-6798insTATATATATATATA, UGT1A9 c.856-6799_856-6798insTATATATATATATA, UGT1A7 c.856-6799_856-6798insTATATATATATATA, UGT1A4 c.868-6799_868-6798insTATATATATATATA, UGT1A8 c.856-6799_856-6798insTATATATATATATA, UGT1A10 c.856-6799_856-6798insTATATATATATATA, UGT1A3 c.868-6799_868-6798insTATATATATATATA ( ENST00000344644.10, ENST00000373445.1, ENST00000373450.5, ENST00000373426.4, ENST00000305139.11, ENST00000373424.5, ENST00000406651.1, ENST00000373414.4, ENST00000354728.5, ENST00000373409.8, ENST00000305208.10, ENST00000482026.6 )
UGT1A6 c.862-6799_862-6798insTATATATATATATA, UGT1A5 c.868-6799_868-6798insTATATATATATATA, UGT1A9 c.856-6799_856-6798insTATATATATATATA, UGT1A7 c.856-6799_856-6798insTATATATATATATA, UGT1A4 c.868-6799_868-6798insTATATATATATATA, UGT1A8 c.856-6799_856-6798insTATATATATATATA, UGT1A10 c.856-6799_856-6798insTATATATATATATA, UGT1A3 c.868-6799_868-6798insTATATATATATATA ( ENST00000344644.10, ENST00000373445.1, ENST00000373450.5, ENST00000373426.4, ENST00000305139.11, ENST00000373424.5, ENST00000406651.1, ENST00000373414.4, ENST00000354728.5, ENST00000373409.8, ENST00000305208.10, ENST00000482026.6 )
Associated Disease
cancer
Source Database
CIViC Evidence
Description
The FDA approved package insert for Belinostat recommends dose adjustment for UGT1A1*28 allele homozygotes.
Variant Origin
Common Germline
Variant Origin
Common Germline
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1792
Gene URL
https://civic.genome.wustl.edu/links/genes/12422
Variant URL
https://civic.genome.wustl.edu/links/variants/729
Rating
5
Evidence Type
Predictive
Disease
Cancer
Evidence Direction
Supports
Drug
Belinostat
Evidence Level
A
Clinical Significance
Adverse Response
Pubmed
26313268
Drugs
Drug NameSensitivitySupported
BelinostatAdverse Responsetrue