Annotation Detail
Information
- Associated Genes
- ALK
- Associated Variants
- ALK ALK FUSIONS ALK ALK FUSIONS
- Associated Disease
- inflammatory myofibroblastic tumor
- Source Database
- CIViC Evidence
- Description
- Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 and immunohistochemistry revealed ALK expression, suggesting ALK fusions in three cases of IMT.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1783
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1
- Variant URL
- https://civic.genome.wustl.edu/links/variants/499
- Rating
- 4
- Evidence Type
- Diagnostic
- Disease
- Inflammatory Myofibroblastic Tumor
- Evidence Direction
- Supports
- Evidence Level
- C
- Clinical Significance
- Positive
- Pubmed
- 10383129
Drugs