Annotation Detail
Information
- Associated Genes
- BRCA1
- Associated Variants
-
BRCA1 LOSS-OF-FUNCTION
BRCA1 LOSS-OF-FUNCTION - Associated Disease
- triple-receptor negative breast cancer
- Source Database
- CIViC Evidence
- Description
- In a study of 26 patients with breast cancer, 10 patients were BRCA-positive and 16 patients were BRCA-negative. Regardless of BRCA status, none showed objective response when treated with olaparib.
- Variant Origin
- germline
- Variant Origin
- Rare Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1775
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6
- Variant URL
- https://civic.genome.wustl.edu/links/variants/185
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Triple-receptor Negative Breast Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 21862407
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Resitance or Non-Reponse | true |