Annotation Detail
Information
- Associated Genes
- PDGFRA
- Associated Variants
-
PDGFRA AMPLIFICATION
(
ENST00000257290.10 )
PDGFRA AMPLIFICATION ( ENST00000257290.10 ) - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In the sunitinib-sensitive adenosquamous NSCLC cell line, PDGFRA expression was associated with focal PFGRA gene amplification, which was similarly detected in a small fraction of squamous cell NSCLC primary tumor specimens. Moreover, in this NSCLC cell line, focal amplification of the gene encoding the PDGFR ligand PDGFC was also detected.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1771
- Gene URL
- https://civic.genome.wustl.edu/links/genes/38
- Variant URL
- https://civic.genome.wustl.edu/links/variants/716
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Sunitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 19366796
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Sunitinib | Sensitivity | true |