Annotation Detail

Information
Associated Genes
FGFR1
Associated Variants
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
Associated Disease
estrogen-receptor positive breast cancer
Source Database
CIViC Evidence
Description
In MDA-MB-134 cells (ER-positive breast cancer cells with amplified FGFR1) ponatinib potently inhibited cell growth with a GI50 value of 23 nmol/L and inhibited FGFR1 phosphorylation with an IC50 value of 7 nmol/L.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/1767
Gene URL
https://civic.genome.wustl.edu/links/genes/1885
Variant URL
https://civic.genome.wustl.edu/links/variants/267
Rating
3
Evidence Type
Predictive
Disease
Estrogen-receptor Positive Breast Cancer
Evidence Direction
Supports
Drug
Ponatinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
22238366
Drugs
Drug NameSensitivitySupported
PonatinibSensitivitytrue