Annotation Detail
Information
- Associated Genes
- SGK1
- Associated Variants
-
SGK1 OVEREXPRESSION
(
ENST00000367858.10 )
SGK1 OVEREXPRESSION ( ENST00000367858.10 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- The alpelisib (PI3Kalpha inhibitor) resistant breast cancer cell line HCC1954 was treated with alpelsisb alone or in combination with the SGK1 kinase inhibitor SGK1-Inh. Addition of SGK1 reduced viability over alpelisib alone, and phospho-S6K as well as phospho-4EBP1 levels decreased with combination treatment. HCC1954 xenografts showed increased tumor volume with treatment of alpelisib or SGK1-Inh alone, but only combination treatment resulted in lack of volume increase and decreased phospho-S6K levels in tumors by IHC.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1731
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5225
- Variant URL
- https://civic.genome.wustl.edu/links/variants/693
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Alpelisib,SGK1-Inh
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 27451907